• Multi-receptor binding and activation studies across GLP-1, GIP, and glucagon receptors
• Comparative pharmacology of single vs. multi-agonist peptides
• Signal transduction pathway characterization in cell-based assays
• Structure-activity relationship (SAR) analysis of peptide modifications
• Receptor selectivity profiling and cross-reactivity studies
• In vitro metabolic signaling pathway investigation
• Peptide stability and proteolytic resistance research

• Storage (Lyophilized): Store at -20°C in original sealed vial. Protect from light and moisture.
• Storage (Reconstituted): Store at 2-8°C for up to 14 days. For extended storage, prepare single-use aliquots and store at -20°C or -80°C. Avoid repeated freeze-thaw cycles.
• Reconstitution: Reconstitute with sterile water or sterile PBS using aseptic technique. Allow to dissolve completely without vigorous agitation.
• Stability: Lyophilized peptide stable for 24 months when stored at -20°C as directed.
• Handling: Wear appropriate personal protective equipment. Handle according to standard laboratory safety protocols for synthetic peptides.

• Certificate of Analysis (CoA) provided with each lot
• HPLC chromatogram confirming ≥98% purity
• Mass spectrometry verification of molecular weight
• Amino acid sequence confirmation
• Sterility testing on lyophilized product
• Endotoxin testing (LAL assay)
• Manufactured under controlled laboratory conditions

Mechanism: This synthetic peptide exhibits agonist activity at three distinct G protein-coupled receptors: glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR).

Structural Features: Engineered peptide sequence incorporating structural modifications to achieve balanced tri-agonist activity while maintaining proteolytic stability and receptor binding affinity.

Reconstitution Guidelines: Typical working concentrations range from 0.1-10 μM depending on assay design and experimental objectives. Addition of 0.1% BSA may minimize peptide adsorption to laboratory plasticware.

Research Context: This compound serves as a reference material for investigating multi-agonist approaches in receptor pharmacology and comparative studies of incretin-based peptides.

Classification: Reference material / Research compound. Research Use Only (RUO).

Intended Use: This product is supplied exclusively for in vitro laboratory research and scientific investigation. Not intended for diagnostic, therapeutic, or any clinical application.

Regulatory Status: This material is not approved for human or veterinary use. Not for drug, diagnostic, household, agricultural, cosmetic, or food applications. Purchaser assumes full responsibility for compliance with all applicable federal, state, and local regulations.

Safety: Handle according to standard laboratory safety practices for synthetic peptides.