Tirz Dual GIP/GLP-1 Receptor Agonist
Dual GIP/GLP-1 Receptor Agonist
Product Specifications ▶
| Compound Class: | Dual GIP/GLP-1 Receptor Agonist |
| Chemical Structure: | Synthetic peptide analog (39 amino acids) |
| Molecular Weight: | 4813.5 g/mol |
| Molecular Formula: | C225H348N48O68 |
| Form: | Sterile lyophilized powder |
| Quantity: | 10 mg per vial |
| Purity: | ≥98% by HPLC analysis |
| Solubility: | Soluble in sterile water or phosphate buffered saline |
Research Applications ▶
- Dual receptor binding and activation studies (GIP and GLP-1 receptors)
- Signal transduction pathway characterization in cell culture models
- Structure-activity relationship (SAR) investigations
- Comparative pharmacology of incretin receptor agonists
- In vitro metabolic regulation studies
- Receptor selectivity and cross-reactivity assays
- Peptide stability and degradation kinetics research
Storage and Handling ▶
- Storage (Lyophilized): Store at -20°C in original sealed vial. Protect from light and moisture.
- Storage (Reconstituted): Store at 2-8°C for up to 14 days. For extended storage, prepare aliquots and store at -20°C or -80°C. Avoid repeated freeze-thaw cycles.
- Reconstitution: Reconstitute with sterile water or sterile PBS using aseptic technique. Allow to dissolve completely without vigorous agitation.
- Stability: Lyophilized peptide stable for 24 months when stored at -20°C as directed.
- Handling: Wear appropriate personal protective equipment. Handle according to standard laboratory safety protocols for peptide compounds.
Quality Control ▶
- Certificate of Analysis (CoA) provided with each lot
- HPLC chromatogram confirming ≥98% purity
- Mass spectrometry verification of molecular weight
- Amino acid composition analysis
- Sterility testing on lyophilized product
- Endotoxin testing (LAL assay)
- Manufactured under controlled laboratory conditions
Technical Information ▶
Mechanism: This synthetic peptide exhibits dual agonist activity at both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors.
Structural Features: Engineered peptide sequence with modifications to enhance receptor binding affinity and proteolytic stability compared to native incretins.
Reconstitution Guidelines: Typical working concentrations range from 0.1-10 μM depending on experimental design. Addition of 0.1% BSA may reduce peptide adsorption to plasticware.
Assay Considerations: Compatible with standard cell-based assays, receptor binding studies, and biochemical characterization methods.
Regulatory Information ▶
Classification: Research compound. Research Use Only (RUO).
Intended Use: This product is supplied exclusively for in vitro laboratory research and scientific investigation. Not intended for diagnostic, therapeutic, or any clinical application.
Regulatory Status: This material is not approved for human or veterinary use. Not for drug, diagnostic, household, agricultural, cosmetic, or food applications. Purchaser assumes full responsibility for compliance with all applicable federal, state, and local regulations.
Safety: Handle according to standard laboratory safety practices for synthetic peptides.